ÄÐÈ˹¬µî

Form: DEF 14A

Definitive proxy statements

May 1, 2001

DEF 14A: Definitive proxy statements

Published on May 1, 2001



SCHEDULE 14A
(RULE 14a-101)

INFORMATION REQUIRED IN PROXY STATEMENT

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities
Exchange Act of 1934 (Amendment No. _______________)

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ] Preliminary Proxy Statement [ ] Confidential, For Use of the
Commission Only (as permitted
[X] Definitive Proxy Statement by Rule 14a-6(e)(2))

[ ] Definitive Additional Materials

[ ] Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

CYTOCLONAL PHARMACEUTICS INC.
- --------------------------------------------------------------------------------
(Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)


Payment of Filing Fee (Check the appropriate box):

[X] No fee required.

[ ] Fee computed on table below per Exchange Act
Rules 14a-6(i)(1) and 0-11.

(1) Title of each class of securities to which transaction applies:

- --------------------------------------------------------------------------------

(2) Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------

(3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

- --------------------------------------------------------------------------------

(4) Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------

(5) Total fee paid:

- --------------------------------------------------------------------------------

[ ] Fee paid previously with preliminary materials:

- --------------------------------------------------------------------------------

[ ] Check box if any part of the fee is offset as provided by Exchange
Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
paid previously. Identify the previous filing by registration statement number,
or the form or schedule and the date of its filing.

(1) Amount previously paid:

- --------------------------------------------------------------------------------

(2) Form, Schedule or Registration Statement no.:

- --------------------------------------------------------------------------------

(3) Filing Party:

- --------------------------------------------------------------------------------

(4) Date Filed:

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CYTOCLONAL PHARMACEUTICS INC.
2110 RESEARCH ROW
SUITE 621
DALLAS, TEXAS 75235
(214) 353-2922

----------

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD MONDAY, JUNE 4, 2001

----------
Dear Stockholder:

NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of
Cytoclonal Pharmaceutics Inc., a Delaware corporation (the "Company"), will be
held at 2110 Research Row, Suite 601, Dallas, Texas 75235, on Monday, June 4,
2001, 9:00 a.m., local time (the "Annual Meeting").

At the Annual Meeting, the stockholders will be requested to act upon
the following matters:

1. To elect seven directors, each for a term of one year or until
their respective successors are elected and qualified;

2. To ratify the selection of Ernst & Young LLP as independent
auditors of the Company for its fiscal year ending December
31, 2001;

3. To approve amendments to the Company's 2000 Stock Option Plan
to (i) increase the number of incentive stock options and
nonqualified stock options available for grant by 1,250,000,
from 1,500,000 to 2,750,000 options, and the number of shares
of Common Stock, $.01 par value per share (the "Common Stock")
of the Company reserved for issuance thereunder by 1,250,000,
from 1,500,000 to 2,750,000 shares of Common Stock; (ii)
change the vesting period for options, such that one-third of
the options vest on the first anniversary of the date of
grant, one-third vest on the second anniversary of the date of
grant and the final third vest on the third anniversary of the
date of grant, rather than half of the options vesting on the
first anniversary of the date of grant and the second half of
the options vesting on the second anniversary of the date of
grant; and (iii) permit new option holders and existing option
holders to exercise their options by cashless exercise of
their options or other means; and

4. To transact such other business as may properly come before
the Annual Meeting or any adjournment thereof.

The close of business on April 16, 2001, has been fixed as the record
date for the determination of stockholders entitled to notice of and to vote at
the Annual Meeting (the "Record Date"). The transfer books of the Company will
remain open following the Record Date.

All stockholders are cordially invited to attend the Annual Meeting.
Whether or not you expect to attend, you are requested to sign, date and return
the enclosed proxy promptly. Stockholders who execute proxies retain the right
to revoke them at any time prior to the voting thereof by filing written notice
of such revocation with the Secretary of the Company, by submission of a duly
executed proxy bearing a later date or by voting in person at the Annual Meeting
of Stockholders. Attendance at the Annual Meeting will not in and of itself
constitute revocation of a proxy. Any written notice revoking a proxy should be
sent to Cytoclonal Pharmaceutics Inc., 2110 Research Row, Suite 621, Dallas,
Texas 75235, Attention: Daniel Shusterman, Secretary. A return envelope which
requires no postage if mailed in the United States is enclosed for your
convenience.

By Order of the Board of Directors,
Daniel Shusterman, Secretary

Dallas, Texas
May 1, 2001





CYTOCLONAL PHARMACEUTICS INC.
2110 RESEARCH ROW
SUITE 621
DALLAS, TEXAS 75235
(214) 353-2922

----------

PROXY STATEMENT

----------

ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD MONDAY, JUNE 4, 2001

This Proxy Statement is furnished in connection with the solicitation
by the Board of Directors of Cytoclonal Pharmaceutics Inc., a Delaware
corporation (the "Company"), of proxies in the enclosed form for the annual
meeting of stockholders to be held at 2110 Research Row, Suite 601, Dallas,
Texas 75235, on Monday, June 4, 2001, at 9:00 a.m., local time (the "Annual
Meeting"), and for any adjournment or adjournments thereof, for the purposes set
forth in the foregoing Notice of Annual Meeting of Stockholders. The persons
named in the enclosed proxy form will vote the shares for which they are
appointed in accordance with the directions of the stockholders appointing them.
If no instructions are given, the persons named in the proxy solicited by the
Board of Directors intend to vote (i) FOR the nominees for election as directors
of the Company named in this Proxy Statement under the caption "Election of
Directors," (ii) FOR the selection of Ernst & Young LLP as independent auditors
of the Company for its fiscal year ending December 31, 2001 and (iii) FOR the
amendments to the Company's 2000 Stock Option Plan as described under the
caption "Amendment of the Company's 2000 Stock Option Plan." Any stockholder
giving such a proxy has the power to revoke the same at any time before it is
voted by (i) filing written notice of such revocation with the Secretary of the
Company, (ii) submission of a duly executed proxy bearing a later date or (iii)
voting in person at the Annual Meeting of Stockholders. Attendance at the Annual
Meeting will not in and of itself constitute a revocation of a proxy. Any
written notice revoking a proxy should be sent to Mr. Daniel Shusterman,
Secretary, Cytoclonal Pharmaceutics Inc., 2110 Research Row, Suite 621, Dallas,
Texas 75235. A return envelope which requires no postage if mailed in the United
States is enclosed for your convenience.

The principal executive offices of the Company are located at 2110
Research Row, Suite 621, Dallas, Texas 75235. The telephone number of the
Company is (214) 353-2922. The approximate date on which this Proxy Statement
and the accompanying form of proxy will first be sent or given to the Company's
stockholders is May 1, 2001 (the "Mailing Date").

VOTING SECURITIES

Only holders of the Company's shares of common stock, par value $.01
per share (the "Common Stock"), and Series A Convertible Preferred Stock, par
value $.01 per share (the "Preferred Stock," and together with the Common Stock,
the "Shares"), of record as of the close of business on the Record Date, are
entitled to vote at the Annual Meeting. On the Record Date, an aggregate of
16,936,885 Shares were issued and outstanding, consisting of 16,171,173 shares
of Common Stock and 765,712 shares of Preferred Stock. Each outstanding share of
Common Stock and each outstanding share of Preferred Stock is entitled to one
(1) vote on all matters to be acted upon at the Meeting. A majority of the
Shares entitled to vote, represented in person or by proxy, constitutes a
quorum. If a quorum is present, a plurality vote of the Shares present, in
person or by proxy, at the Annual Meeting and entitled to vote is required for
the election of any director in Proposal 1. A majority vote of the issued and
outstanding Shares entitled to vote at the Annual Meeting is required for (i)
approval of Ernst & Young LLP as the Company's independent auditors in Proposal
2 and (ii) approval of the amendments to the Company's 2000 Stock Option Plan in
Proposal 3. In case a quorum shall not be present at the Annual Meeting, a
majority in interest of the stockholders entitled to vote



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at the Annual Meeting, present in person or by proxy, shall have the power to
adjourn such Annual Meeting from time to time, without notice other than
announcement at the Annual Meeting until the requisite amount of Shares entitled
to vote shall be present. Abstentions are considered Shares present and entitled
to vote and, therefore, have the same legal effect as a vote AGAINST a matter
presented at the Annual Meeting. Any Shares held in street name for which the
broker or nominee receives no instructions from the beneficial owner, and as to
which such broker or nominee does not have discretionary voting authority, will
be considered as Shares not entitled to vote and will therefore not be
considered in the tabulation of the votes. Proxy ballots are received and
tabulated by the Company's transfer agent, American Stock Transfer & Trust Co.,
and certified by the inspector of election.

PROPOSAL 1

ELECTION OF DIRECTORS

At the Annual Meeting, seven (7) directors will be elected by the
stockholders to serve until the next annual stockholder meeting or until their
successors are elected and qualified. The accompanying form of proxy will be
voted FOR the election of the nominees listed below to serve as directors unless
the proxy contains contrary instructions. Management has no reason to believe
that the nominees will not be candidates or will be unable to serve as
directors. However, in the event that the nominees should become unable or
unwilling to serve as directors, the proxy will be voted FOR the election of
such persons as shall be designated by the directors.

The following table sets forth the name and age of each
director-nominee and the year during which each individual initially began
serving as a director of the Company:

DIRECTOR NOMINEES:



NAME AGE YEAR FIRST BECAME A DIRECTOR
- ---- --- ----------------------------


Ronald L. Goode, Ph.D. 57 2001
Arthur P. Bollon, Ph.D. 58 1991
Robert J. Easton(2) 57 2000
Gary E. Frashier(2) 64 1999
Ira J. Gelb, M.D.(1)(2) 73 1994
Irwin C. Gerson(1)(2) 71 1995
Walter M. Lovenberg, Ph.D.(1) 66 1995


- ----------
(1) Member of the Audit Committee

(2) Member of the Compensation Committee


THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS A VOTE "FOR" THE ELECTION OF
THE ABOVE-NAMED NOMINEES AS DIRECTORS. PROXIES SOLICITED BY THE BOARD OF
DIRECTORS WILL BE SO VOTED UNLESS STOCKHOLDERS SPECIFY OTHERWISE IN THEIR
PROXIES.


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DIRECTORS AND OFFICERS




YEAR BECAME
NAME AGE OFFICER/DIRECTOR POSITION
---- --- ---------------- --------


Ronald Lane Goode, Ph.D. 57 2001 President, Chief Executive Officer
and Director

Gary E. Frashier (2) 64 1999 Non-Executive Chairman of the Board

Arthur P. Bollon, Ph.D. 58 1991 Founder and Vice Chairman of the
Board

Robert J. Easton (2) 57 2000 Director

Ira J. Gelb, M.D. (1)(2) 73 1994 Director

Irwin C. Gerson (1)(2) 71 1995 Director

Walter M. Lovenberg, Ph.D. (1) 66 1995 Director

Dorit Arad, Ph.D. 48 1999 Executive Vice President of Drug
Design

Joan H. Gillett, CPA 51 2000 Vice President and Controller

Robert J. Rousseau, Ph.D. 61 2001 Vice President of Business
Development and Licensing

Daniel Shusterman, J.D. 37 1991 Vice President, Administration,
General Counsel and Secretary


- ----------

(1) Member of Audit Committee

(2) Member of Compensation Committee

BIOGRAPHICAL INFORMATION:

Certain information about the officers and directors is set forth
below. This information has been furnished to the Company by the individuals
named.

Ronald Lane Goode, Ph.D. was named President and Chief Executive
Officer and elected to the Board of Directors on March 21, 2001. Dr. Goode is an
accomplished pharmaceutical executive who has held key management positions at
G. D. Searle & Co. (Corporate Senior Vice President and President of
Asia/Pacific World Area from 1995 to 1997, President of Searle International
from 1991 to 1995, and Senior Vice President of Commercial Development from 1986
to 1989) and before that at Pfizer Pharmaceuticals (Vice President of Clinical
Research and Scientific Affairs from 1985 to 1986 and Director of Marketing
Research in 1980). He has an extensive record of success in business
development, having been responsible for many of Searle's acquisitions,
including DayPro(C), which became Searle's largest selling drug. Dr. Goode has
supervised clinical development programs that led to the filing of over a dozen
New Drug Approval applications, including Procardia XL(C) (which became Pfizer's
leading product) and Ambien(C), which now dominates the sleep aid market for
Searle. After his tenure at Searle, Dr. Goode was President



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and CEO of Unimed Pharmaceuticals, Inc. from 1997 to 1999 where he launched that
company's first product. He also positioned the company for sale to Solvay Et
Cie, the Belgium-based conglomerate. Most recently he formed the consulting
company Pharma-Links in 1999 with the mission of being the "link" between
pharmaceutical companies to help them create alliances, form joint ventures and
effect various transactions. Dr. Goode received his Ph.D. in Microbiology from
the University of Georgia.

Gary E. Frashier commenced serving as a director of the Company on June
28, 1999 and was elected to Chairman in a non-executive capacity in December
2000. Mr. Frashier serves as President and Principal of Management Associates,
which provides strategic consulting services to entrepreneurial companies in the
life sciences field. Mr. Frashier previously served as Chairman of the Board and
Chief Executive Officer of OSI Pharmaceuticals, Inc. ("OSIP"), a Nasdaq listed
company, from January 1997 through September 1998, and as Chairman of the Board
through September 2000. He previously served as CEO and Vice-Chairman of OSIP
during 1996, and as President and CEO of OSIP from March 1990 through December
1995. From March 1987 through February 1990, Mr. Frashier served as President
and CEO of Genex Corporation, which specialized in protein engineering.
Previously, Mr. Frashier served as Executive Vice President of Millipore
Corporation, where he was also President of Waters Associates, Inc., a leader in
liquid chromatography. At Millipore, Mr. Frashier also served as President,
International Operations. In 1984, Mr. Frashier organized a management buyout of
Millipore's ultra high-purity and laboratory water systems business, Continental
Water Systems, Inc., which was later sold to Olin Corporation. Mr. Frashier has
a B.S. in chemical engineering from Texas Technological University, where he was
honored in 1985 as a Distinguished Engineer of the University. In 1970, he
received his M.S. degree in Management from the Massachusetts Institute of
Technology, where he was selected as a Sloan Fellow in Management. He was also
selected as the "Long Island Businessman of the Year" in 1993 by the Wharton
Club. He is a registered Professional Engineer in chemical engineering, a member
of the society of Sloan Fellows (MIT) and a former member of the Young
President's Organization. Mr. Frashier serves on the Boards of several private
and public biopharmaceutical firms, including Maxim Pharmaceuticals, Inc., which
is a Nasdaq listed public company.

Arthur P. Bollon, Ph.D., founder of the Company, currently serves as
Vice Chairman in a non-executive capacity. Prior thereto he had served as
Chairman of the Board of Directors, President and Chief Executive Officer from
the Company's inception in 1991 and until March 1995, as Treasurer. Dr. Bollon
received his Ph.D. from the Institute of Microbiology at Rutgers University and
was a Post Doctoral Fellow at Yale University. Dr. Bollon has served as a
consultant to a number of major companies, including Merck & Co., Inc., Sharp &
Dohme and Diamond, Shamrock, and has served on the Board of Directors and
Advisory Boards of several biotechnology companies, including Viragen, Inc.,
Wadley Biosciences Corp. and American Bio-netics, Inc. From 1987 to 1991, Dr.
Bollon served as President and Chief Executive Officer of the Wadley/Phillips
Partnership. Prior to that time, he was Director of Genetic Engineering and
Chairman of the Department of Molecular Genetics at the Wadley Institutes of
Molecular Medicine. In his capacities at the Wadley/Phillips Partnership and
Wadley Institutes, Dr. Bollon played a leading role in bringing the technology
that forms the basis of the Company from conception to reality.

Robert J. Easton, was elected to the Board of Directors in December
2000. Mr. Easton recently founded a health care consulting practice named Easton
Associates LLC. Prior to this latest venture, he spent 18 years as a management
consultant, most recently as Managing Director with IBM Healthcare Consulting
("IBM"). Prior to IBM, Mr. Easton served as President of the Wilkerson Group,
also a health care consulting concern. Mr. Easton has executed proprietary
studies in a wide variety of medical products and service fields. His areas of
expertise include pharmaceuticals, biotechnology and in vitro diagnostics. Mr.
Easton is a frequent speaker for medical industry and investment groups in the
U.S. and Europe. He is a Director of CollaGenex Pharmaceuticals, Inc., a Nasdaq
listed company, and two private companies, the former President of the
Biomedical Marketing Association, and Special Limited Partner of Advanced
Technology Ventures. Mr. Easton received an M.B.A. from Harvard Graduate School
of Business Administration and undergraduate degrees in Chemical Engineering
from Rice University.

Ira J. Gelb, M.D. has been a director of the Company since April 1994.
Dr. Gelb received his M.D. from New York University School of Medicine in 1951.
After finishing his training in cardiology at the Mount Sinai Hospital in New
York City in 1957, Dr. Gelb continued his association with that institution
until his retirement in 1992. During



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this period, he was appointed Attending Cardiologist and Associate Clinical
Professor at the Mount Sinai School of Medicine. Other appointments included
Adjunct Associate Clinical Professor of Cardiology at Cornell Medical School,
Adjunct Clinical Professor of Cardiology at New York Medical College, Cardiology
Consultant at Lawrence Hospital, Bronxville, N.Y. and United Hospital,
Portchester, N.Y. Dr. Gelb is a former President of the American Heart
Association, Westchester-Putnam Chapter, and was a Senior Assistant Editor with
the American Journal of Cardiology from 1968 to 1983, when he became a founding
editor of the Journal of the American College of Cardiology ("JACC"). Dr. Gelb
continued as a Senior Assistant Editor of JACC until his retirement in 1992.
Since that time, he has served on the boards of various pharmaceutical
companies. Since 1992, Dr. Gelb has been an Honorary Lecturer at The Mount Sinai
School of Medicine. Dr. Gelb has also served as the Clinical Coordinator of
Biomedical Programs and Professor of Chemistry & Biochemistry at Florida
Atlantic University ("FAU") since 1998, an Adjunct Professor and a member of
FAU's Foundation Board since October 1996 and FAU's Steering Committee since
1997. Dr. Gelb has served as a member of the Board of Directors of the American
Heart Association, Boca Raton Division, since December 1996 and was appointed
President in June 1999. In 1998, Boca Raton Community Hospital added Dr. Gelb as
a member to its Foundation Board. In November 1998, Dr Gelb was appointed
Voluntary Professor of Medicine at the University of Miami School of Medicine.
At present he is Director of Clinical Programs and Clinical Professor,
Biomedical Science, Charles E. Schmidt College of Science, Florida Atlantic
University and in 1999 was appointed to the advisory board of Cleveland Clinic,
Florida.

Irwin C. Gerson has been a director of the Company since March 1995.
From 1995 until December 1998, Mr. Gerson served as Chairman of Lowe McAdams
Healthcare and prior thereto had been, since 1986, Chairman and Chief Executive
Officer of William Douglas McAdams, Inc., one of the largest advertising
agencies in the U.S. specializing in pharmaceutical marketing and communications
to healthcare professionals. In February 2000, he was inducted into the Medical
Advertising Hall of Fame. Mr. Gerson has a B.S. in Pharmacy from Fordham
University and an MBA from the NYU Graduate School of Business Administration.
He is a director of Andrx Corporation, a Nasdaq listed public company, and Bio
Sample Inc., a privately held corporation. In 1992, Mr. Gerson received an
honorary Doctor of Humane Letters from the Albany College of Pharmacy. Mr.
Gerson served as a Trustee of Long Island University, Chairman of The Council of
Overseers -- Arnold and Marie Schwartz College of Pharmacy, member of the Board
of Trustees of the Albany College of Pharmacy and, from 1967 through 1974, was a
lecturer on sales management and pharmaceutical marketing at the Columbia
College of Pharmacy. He is currently a director of the Lifetime Learning Society
of Florida Atlantic University. Mr. Gerson also has served as a Member of the
Board of Governors, American Association of Advertising Agencies, a Director and
Chairman of Business Publications Audit, a Director of the Connecticut Grand
Opera, and a Director of the Stamford Chamber Orchestra. Mr. Gerson previously
served as a director of the foundation of Pharmacists and Corporate Americans
for AIDS Education, the Pharmaceutical Advertising Council, the Nutrition
Research Foundation and as a Trustee of the Chemotherapy Foundation. He was also
on the boards of Penn Dixie Industries and Continental Steel Corporation.

Walter M. Lovenberg, Ph.D. has been a director of the Company since
August 1995. From 1989 to 1993, Dr. Lovenberg served as Executive Vice President
and member of the Board of Directors of Marion Merrell Dow Inc. Dr. Lovenberg
also served as the President of the Marion Merrell Dow Research Institute from
1989 to 1993 and Vice President from 1986 through 1989. Prior to joining Marion
Merrell Dow in 1958, Dr. Lovenberg was a Senior Scientist and Chief of
Biochemical Pharmacology at the National Institutes of Health. Dr. Lovenberg has
served as President of Lovenberg Associates, Inc. since 1993. From 1997 to 2000,
Dr. Lovenberg served as Chief Executive Officer of Helicon Therapeutics Inc., a
private company, and since 1992 and 1995, Dr. Lovenberg has served as a director
of Xenometrix, Inc. and Chairman of the Board of Inflazyme Pharmaceutics, Ltd.
(which is traded on the Toronto Exchange), respectively. Also, since 1994, Dr.
Lovenberg has served as a director of OSI Pharmaceuticals, Inc., a Nasdaq listed
public company. Dr. Lovenberg serves on the Scientific Advisory Board of
Guilford Pharmaceuticals, Inc., a Nasdaq listed company. Dr. Lovenberg is also a
director of several private biotechnology companies. Dr. Lovenberg received a
Ph.D. in Biochemistry from George Washington University in 1962, and prior to
that, a B.S. in Biochemistry and an M.S. in Agriculture from Rutgers University.
Dr. Lovenberg, who serves as Executive Editor of Analytical Biochemistry and
Editor (USA) of Neurochemistry International, is a consulting editor to several
other scientific journals. Dr. Lovenberg has been the recipient of many awards,
including a Fulbright-Hays Senior Scholar Award and a Public Health Service
Superior Service Award. Dr. Lovenberg is a member of the American College of



-6-


Neuropsychopharmacology, the American Society of Neurochemistry and the American
Society of Biochemistry and Molecular Biology.

Dorit Arad, Ph.D. joined us as Vice President of Drug Design in January
1999 and was named Executive Vice President of Drug Design in September 1999.
From 1996 until 1998, Dr. Arad served as Scientific Director at Saturi Medical
Research LTD. From 1991 until 1993, Dr. Arad served as a consultant to
Teva-Israel Pharmaceutical Industries. In addition, Dr. Arad has served as an
instructor and lecturer at Technion in Haifa, Israel and as a lecturer at the
Tel-Aviv University. Dr. Arad is the co-author of a number of scientific
articles and papers. Dr. Arad received her B.Sc., M.Sc. and D.Sc. Degrees in
Chemistry from Technion, Haifa, Israel.

Joan H. Gillett, CPA, joined us in October 2000 as Vice President,
Controller and Principal Accounting Officer. From 1997 to August 2000, Ms.
Gillett served as the Chief Financial Officer for International Isotopes Inc., a
publicly held radiopharmaceutial development and manufacturing company, where
she was responsible for all accounting, financial reporting, and investment
activities. From 1986 to 1996, she held various positions for Life Savings Bank
in Austin, Texas. Those positions included Director, Chief Financial Officer and
President.

Robert J. Rousseau, Ph.D., joined the Company in March 2001 as Vice
President of Business Development and Licensing. Dr. Rousseau served as Director
of New Technologies Licensing at Hoechst Marion Roussel, Inc. and has an MBA
from Rockhurst University and a Ph.D. in Chemistry from the University of Utah.
He founded Rondeau Medical Associates Inc., a consulting company involved in new
technology identification, development of an extensive contact network and
establishment of licensing agreements for numerous biotechnology and
pharmaceutical companies. Prior to Rondeau, he managed the gene transcription
modulator-out licensing program for OSI Pharmaceuticals, Inc., resulting in
licensing agreements with Merck, Sharp & Dohme, Pharmacia and Upjohn, Johnson &
Johnson, American ÄÐÈ˹¬µî Products and Aurora Biosciences. Prior to OSI, he spent
12 years as Director of New Technologies Licensing at Hoechst Marion Roussel,
Inc. where he was responsible for closing agreements with Immulogic,
TransKaryotic Technologies (TKT), Albany Molecular Research and Development,
Scios Nova, Gensia, Affymax, Oncogene Sciences and Alliance Pharmaceuticals. Dr.
Rousseau's previous positions included both Director of Operations and Director
of Marketing at Analytical Systems, Division of Marion Laboratories; Director of
Clinical Chemistry Research/Director of West Coast Operations, Hyland Division
of Baxter Travenol; Technical Liaison Officer, Curtis Nuclear Corporation; and
Head of BioOrganic Chemistry, ICN Nucleic Acid Research Institute. Dr. Rousseau
is the holder of seven patents, the author of more than 33 scientific
publications and the recipient of two Presidential Awards and three Special
Achievements Awards from Marion Laboratories.

Daniel M. Shusterman, J.D., M.S. was named our Vice President,
Administration and General Counsel in October 2000. Prior to that he was named
Vice President of Operations in 1994 and Treasurer and Chief Financial Officer
in March 1995, after having served as our Director of Operations since he joined
us in 1991. Mr. Shusterman received his M.S. degree with an emphasis on
biotechnology from the University of Texas in 1988. He was Director of
Operations at Wadley/Phillips Partnership for three years prior to joining us.
Mr. Shusterman is a registered Patent Agent and received his J.D. from Texas
Wesleyan University School of Law in 1993 and has been a member of the Texas bar
since 1994.

MEETINGS OF THE BOARD:

During the fiscal year ended December 31, 2000, there were ten (10)
meetings of the Board of Directors, and eleven (11) actions by unanimous
consent. The Board of Directors has an Audit Committee and Compensation
Committee. During the fiscal year ended December 31, 2000, there were three (3)
formal meetings of the Audit Committee and three (3) formal meetings of the
Compensation Committee. Each director of the Company attended all Board meetings
and committee meetings of which he was a member at such time during the fiscal
year ended December 31, 2000.



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COMMITTEES OF THE BOARD OF DIRECTORS:

The Audit Committee serves at the pleasure of the Board of Directors,
and is authorized to review proposals of the Company's auditors regarding annual
audits, recommend the engagement or discharge of the auditors, review
recommendations of such auditors concerning accounting principles and the
adequacy of internal controls and accounting procedures and practices, to review
the scope of the annual audit, to approve or disapprove each professional
service or type of service other than standard auditing services to be provided
by the auditors, and to review and discuss the audited financial statements with
the auditors. Its members are Ira J. Gelb, M.D., Irwin C. Gerson and Walter
Lovenberg, Ph.D. The Board of Directors adopted a written charter for the Audit
Committee on June 4, 2000, a copy of which is attached hereto as Appendix A.

The Compensation Committee serves at the pleasure of the Board of
Directors, and is authorized to establish salaries, incentives and other forms
of compensation for officers, directors and certain key employees and
consultants, administer the Company's various incentive compensation and benefit
plans, including the Company's 1992 Stock Option Plan, 1996 Stock Option Plan
and 2000 Stock Option Plan and recommend policies relating to such plans. Its
members are Gary E. Frashier, Robert J. Easton, Irwin C. Gerson and Ira J. Gelb,
M.D.

The Company does not have a formal Stock Option Committee, Nominating
Committee or Executive Committee of the Board of Directors.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE:

Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires the Company's officers, directors and persons who beneficially own more
than 10% of a registered class of the Company's equity securities to file with
the Securities and Exchange Commission (the "Commission") initial reports of
ownership and reports of changes in beneficial ownership of common stock and
other equity securities of the Company. Such officers, directors and greater
than 10% beneficial owners are required by the Commission's regulations to
furnish the Company with copies of all Section 16(a) forms filed by such
reporting persons.

Based solely upon the Company's review of such forms furnished to the
Company and written representations from certain reporting persons, the Company
believes that Company's officers, directors and greater than 10% beneficial
owners have complied with all applicable filing requirements, except that Joan
H. Gillett, Vice President and Controller, was late in filing her Form 3 in the
fiscal year ended December 31, 2000.


EXECUTIVE COMPENSATION

The following summary compensation table sets forth the aggregate
compensation paid by the Company to its Chief Executive Officer and to the
Company's most highly compensated officers whose annual compensation exceeded
$100,000 for the fiscal year ended December 31, 2000 (each, a "Named Officer")
for services during the fiscal years ended December 31, 2000, 1999 and 1998:




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SUMMARY COMPENSATION TABLE



Long-Term
Compensation
------------
Annual Compensation Awards
-------------------------------------------------------- ------------

Securities
Underlying
Name and Other Compensation Stock
Principal Position Year Salary($) Bonus($) ($)(1) Options #
------------------ ---- --------- -------- ------------------ -----------


Arthur P. Bollon, Ph.D. 2000 $220,769 -- $6,000 75,000
- -Formerly Chief Executive Officer and 1999 $205,988 -- $6,000 25,000
President, currently Vice Chairman 1998 $186,230 -- $6,000 100,000

Dorit Arad, Ph.D. 2000 $130,384 -- $1,615 15,000
- -Executive Vice President of Drug 1999 $101,923 - - 125,000
Design 1998 - - - -

Daniel M. Shusterman, J.D. 2000 $110,038 - $6,000 10,000
- -Vice President, Administration and 1999 $ 90,865 - $6,000 15,000
General Counsel 1998 $ 87,533 - $1,615 25,000


- ----------
(1) Consisting of car allowances.

During the fiscal year ended December 31, 2000, deliberations
concerning officer compensation were made by the Company's Compensation
Committee.




-9-


OPTION GRANTS IN FISCAL 2000:

The following table sets forth certain information with respect to
options granted to the Named Officers during the year ended December 31, 2000:



OPTION/SAR GRANTS IN FISCAL YEAR 2000

Individual Grants
----------------------------------------------------------------------------

Number of Percent of Total
Securities Options/SARs
Underlying Granted to Exercise or
Options/SARs Employees in Base
Name Granted(#) Fiscal Year(1) Price($/Sh) Expiration Date
---- ------------ ---------------- ----------- ---------------


Arthur P. Bollon, Ph.D., 75,000 30.4% 7.438 January 14, 2010
- -Formerly Chief Executive
Officer and President,
Currently Vice Chairman

Dorit Arad, Ph.D 15,000 6.1% 7.438 January 14, 2010
- -Executive Vice President
of Drug Design

Daniel M. Shusterman, J.D. 10,000 4.0% 7.438 January 14, 2010
- -Vice President,
Administration and General
Counsel


- ----------

(1) Excludes grants to non-employee directors and consultants.



-10-


AGGREGATED OPTION/SAR EXERCISES IN LAST FISCAL YEAR
AND FY-END OPTION/SAR VALUES



Number of Securities Value of
Underlying Unexercised In-
Unexercised the-Money
Options/SARs at Options/SARs at
Shares FY-End(#) FY-End(#)
Acquired on Value Exercisable/ Exercisable/
Name Exercise(#) Realized($) Unexercisable Unexercisable(1)
---- ------------ ----------- -------------------- -------------------


Arthur P. Bollon, Ph.D. 0 0 540,000/105,000 $3,982,500/$774,375
Dorit Arad, Ph.D. 0 0 75,000/15,000 $553,125/$479,375
Daniel M. Shusterman, J.D. 0 0 84,000/26,000 $619,500/$191,750


(1) Based on the fair market value of the Company's Common Stock on December 31,
2000, as quoted on the Nasdaq National Market.

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS
AND MANAGEMENT

Generally, under the Securities Exchange Act of 1934, a person is
deemed to "beneficially own" securities which that person has the right to
acquire within 60 days. The following table sets forth certain information
regarding the beneficial ownership of our capital stock as of March 27, 2001, by
each person deemed to be the beneficial owner of more than 5% of any class of
our capital stock, each of our directors, each Named Officer and all directors
and officers as a group. Except as otherwise indicated, each of the persons
named has sole voting and investment power with respect to the shares shown
below.



Common Stock Series A Preferred Stock
------------------------------------ ---------------------------------------------------

Amount and Nature Amount and Nature Percent of all
Name and Address of Beneficial Percent of Class of Beneficial Percent of Voting Securities
of Beneficial Owner(1) Ownership(2) (2) Ownership(3) Class(3) (4)
---------------------- ----------------- ---------------- ----------------- ---------- -----------------


Roan/Meyers Associates, L.P.(5) ..... 1,590,549 9.7% 29,282 3.7% 9.5%

Bruce Meyers(6) ..................... 1,509,020 9.3% 29,282 3.7% 9.0%

Arthur P. Bollon, Ph.D.(7) .......... 769,900 4.6% -- -- 4.3%

Dorit Arad, Ph.D.(8) ................ 122,500 0 -- -- 0

Robert J. Easton(9) ................. 25,000 * -- -- *

Gary E. Frashier(10) ................ 98,500 * -- -- *

Ira J. Gelb, M.D.(11) ............... 162,500 1% -- -- *

Irwin C. Gerson(12) ................. 158,500 1% -- -- *

Ronald L. Goode, Ph.D.(13) ......... 200,000 1.2% -- -- 1.1%

Walter M. Lovenberg, Ph.D.(14) ...... 161,000 1% -- -- *

Daniel M. Shusterman, J.D.(15) ...... 94,000 * -- -- *

Directors and officers as a group 1,792,900 10% -- -- 9.6%
(11 persons)(16) ....................


- ----------
* Less than 1%



-11-


Except as otherwise indicated, each of the persons named has sole voting and
investment power with respect to the shares shown below.

(1) Except as otherwise indicated, the address of each beneficial owner is
c/o the Company, 2110 Research Row, Suite 621, Dallas, Texas 75235.

(2) Calculated on the basis of 16,150,773 shares of Common Stock
outstanding except that shares of Common Stock underlying options or
warrants exercisable within 60 days of the date hereof are deemed to be
outstanding for purposes of calculating the beneficial ownership of
securities of the holder of such options or warrants. This calculation
excludes shares of Common Stock issuable upon the conversion of Series
A Preferred Stock.

(3) Calculated on the basis of 786,112 shares of Series A Preferred Stock
outstanding.

(4) Calculated on the basis of an aggregate of 16,150,773 shares of Common
Stock and 786,112 shares of Series A Preferred Stock outstanding except
that shares of Common Stock underlying options and warrants exercisable
within 60 days of the date hereof are deemed to be outstanding for
purposes of calculating beneficial ownership of securities of the
holder of such options or warrants. This calculation excludes shares of
Common Stock issuable upon the conversion of Series A Preferred Stock.

(5) The address for Roan/Meyers Associates, L.P. ("RMA") (formerly,
Janssen-Meyers Associates, L.P.) is 17 State Street, New York, New York
10004. Mr. Bruce Meyers is a 100% stockholder and the sole officer and
director of the corporate general partner of RMA. Includes (i) 81,529
shares of Common Stock issuable upon the exercise of a Unit Purchase
Option and underlying Class E Warrants granted to RMA for placement
agent services in connection with the Company's April 1998 private
placement (the "April 1998 Private Placement") and (ii) the aggregate
amount of shares of Common Stock and Series A Preferred Stock
beneficially owned by Mr. Meyers. See (6) below.

(6) Mr. Meyers' address is c/o RMA referenced in note (5) above. Consists
of (i) 1,444,470 shares of Common Stock , (ii) 33,987 shares of Common
Stock issuable upon the exercise of a currently exercisable Unit
Purchase Option and underlying Class E Warrants granted to RMA for
placement agent services in connection with the April 1998 Private
Placement, (ii) 1,510 shares of Common Stock issuable upon the exercise
of 377.5 Unit Purchase Options and underlying C and D Warrants
originally granted to RMA for underwriting services in connection with
the IPO, (iii) 30,563 shares of Common Stock issuable upon the exercise
of currently exercisable Class E Warrants, (iv) 35,800 shares of Common
Stock held by The Meyers Foundation of which Mr. Meyers has voting
control. Does not include 29,282 shares of Common Stock issuable upon
the conversion of 29,282 shares of Series A Preferred Stock. See note
(5) above.

(7) Ownership consists of 167,400 shares of Common Stock and options to
purchase 602,500 shares of Common Stock which are currently exercisable
or exercisable within 60 days of the date hereof. Does not include
options to purchase 67,500 shares of Common Stock not exercisable
within 60 days of the date hereof.

(8) Ownership consists of 25,000 shares of Common Stock and options to
purchase 97,500 shares of Common Stock currently exercisable or
exercisable within 60 days of the date hereof. Does not include options
to purchase 42,500 shares of Common Stock not exercisable within 60
days of the date hereof.

(9) Ownership consists of options to purchase 25,000 shares of Common Stock
currently exercisable or exercisable within 60 days of the date hereof.
Does not include options to purchase 50,000 shares of Common Stock not
exercisable within 60 days of the date hereof.




-12-


(10) Ownership consists of options to purchase 98,500 shares of Common Stock
currently exercisable or exercisable within 60 days of the date hereof.
Does not include options to purchase 121,500 shares of Common Stock not
exercisable within 60 days of the date hereof.

(11) Ownership consists of options to purchase 162,500 shares of Common
Stock which are currently exercisable or exercisable within 60 days of
the date hereof. Does not include options to purchase 16,500 shares of
Common Stock not exercisable within 60 days of the date hereof.

(12) Ownership consists of options to purchase 158,500 shares of Common
Stock which are currently exercisable or exercisable within 60 days of
the date hereof. Does not include options to purchase 16,500 shares of
Common Stock not exercisable within 60 days of the date hereof.

(13) Ownership consists of options to purchase 200,000 shares of Common
Stock which are currently exercisable or exercisable within 60 days of
the date hereof. Does not include options to purchase 200,000 shares of
Common Stock which are not currently exercisable within 60 days of the
date hereof.

(14) Ownership consists of 2,500 shares of Common Stock and options to
purchase 158,500 shares of Common Stock currently exercisable or
exercisable within 60 days of the date hereof. Does not include options
to purchase 16,500 shares of Common Stock not exercisable within 60
days of the date hereof.

(15) Ownership consists of 5,000 shares of Common Stock and options to
purchase 89,000 shares of Common Stock currently exercisable or
exercisable within 60 days of the date hereof. Does not include options
to purchase 16,000 shares of Common Stock not exercisable within 60
days of the date hereof.

(16) Ownership consists of 200,900 shares of Common Stock and options to
purchase an aggregate of 1,592,000 shares of Common Stock which are
currently exercisable or exercisable within 60 days of the date hereof.
Does not include options to purchase 923,000 shares of Common Stock not
exercisable within 60 days of the date hereof.


EMPLOYMENT CONTRACTS AND TERMINATION OF EMPLOYMENT AND CHANGE-IN-CONTROL
ARRANGEMENTS:

Ronald Lane Goode, Ph.D. entered into an employment agreement with the
Company on March 21, 2001, whereby Dr. Goode agreed to serve as the Company's
President and Chief Executive Officer until March 20, 2004. The employment
agreement provided for the payment to Dr. Goode of a base salary of $350,000 per
year with an annual bonus payment of up to 60% of Dr. Goode's base salary, as
determined by the Board's discretion. The employment agreement provides that in
the event Dr. Goode's employment is terminated by the Company without cause (as
such term is defined in the employment agreement), then Dr. Goode shall receive
severance payments of equal monthly installments at the base rate until either
(i) the expiration of 24 months following the termination date, if such date is
prior to March 21, 2003, or (ii) the expiration of 18 months following the
termination date, if such date is after March 20, 2003. Such payments shall also
become payable to Dr. Goode if a change of control of the Company occurs or if
the Company breaches the employment agreement. In addition, the Company granted
to Dr. Goode an option to purchase up to 400,000 shares of the Company's common
stock at an exercise price of $3.25 per share. Under the employment agreement,
Dr. Goode will also receive a car allowance at a rate to be determined.

Arthur P. Bollon, Ph.D. is employed by us under an employment agreement
extended through November 6, 2003. The employment agreement provides for the
payment to Dr. Bollon of a base salary of $250,000 per year. In addition, in the
event Dr. Bollon is terminated without just cause or due to a disability, the
employment agreement provides that Dr. Bollon shall receive severance payments
of equal monthly installments at the base rate until the expiration of the term.

Since 1999, Dr. Dorit Arad has been employed by the Company as Vice
President for Drug Design pursuant to an employment agreement dated December 31,
1998, for an initial term of three years. Pursuant to the agreement,



-13-



Dr. Arad received a grant of options to purchase 75,000 shares of Common Stock.
The agreement also provides that Dr. Arad receives up to $5,000 per month for
computer laboratory, office and personal expenses incurred on the Company's
behalf in Israel. In December 1999, Dr. Arad was promoted to Executive Vice
President of Drug Design. Pursuant to such promotion, Dr. Arad received a salary
increase to $125,000 per year and a grant of options to purchase 50,000 shares
of Common Stock. In September 2000, Dr. Arad's compensation was increased to
$145,000 per year and she received a $500 a month car allowance.

Mr. Shusterman has been employed by the Company since 1991. Pursuant to
an employment agreement, Mr. Shusterman was named Vice President of Operations
and Chief Financial Officer effective November 1995, for an initial term of
three years at a yearly salary of $75,000. In September 1998, the employment
agreement was extended for an additional three years and he received a salary
increase to $90,000 per year and a $500 per month car allowance. In September
2000, his compensation was increased to $145,000 per year. In October 2000 Mr.
Shusterman was named Vice President, Administration and General Counsel.

Each of the Company's officers and the Company's principal scientists
have entered into confidentiality and patent assignment agreements with the
Company.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION:

The Compensation Committee consists of Gary E. Frashier, Robert J.
Easton, Ira J. Gelb, M.D. and Irwin C. Gerson. No member of the Compensation
Committee is a current or former officer or employee of the Company. There are
no compensation committee interlocks between the Company and any other entities
involving any of the officers or directors of such other entities.

INSURANCE FOR INDEMNIFICATION OF DIRECTORS AND OFFICERS:

The Company has in effect, with Liberty Surplus Insurance Company,
through Budget Installment Corporation, under a policy effective from September
15, 2000 to September 15, 2001, insurance covering all of its current directors
and officers against certain liabilities and reimbursing the Company for
obligations it incurs as a result of its indemnification of such directors and
officers. The annual premium is $195,000.


COMPENSATION OF DIRECTORS:

Each director who is not an officer or an employee of the Company (an
"Outside Director") received $1,500 per month in compensation through February
2000. Commencing March 2000, each Outside Director received $500 for each
conference call or committee meeting attended and $1,500 for each board meeting
attended. As of January 5, 2001, Directors receive fees of $1,500 per month and
$1,500 per day per board meeting, $750 per committee meeting attended, $1,000
per board meeting conference call attended and $500 per committee meeting
conference call attended. Directors are also reimbursed for expenses actually
incurred in connection with their attendance at meetings of the Board of
Directors.

During the fiscal year ended December 31, 2000, five (5) Outside
Directors received options to purchase an aggregate 195,000 shares of Common
Stock. More specifically, in January 2000, Gary E. Frashier, Ira J. Gelb, Irwin
C. Gerson and Walter M. Lovenberg, all Outside Directors, each received options
to purchase 25,000 Shares of Common Stock exercisable at $7.438 per share. In
October 2000, Gary Frashier received additional options to purchase 20,000
shares of Common Stock excerisable at $8.563 per share. All such options vest
50% on the first anniversary of the date of grant and 50% on the second
anniversary of the date of grant. In December 2000, Robert J. Easton, an Outside
Director, received options to purchase 50,000 shares of Common Stock excerisable
at $7.43 per share. Such options vest 20% on each of the first five
anniversaries of the date of the grant. In January 2000, the Company granted
Arthur P. Bollon, Vice Chairman of the Board, options to purchase 75,000 shares
of Common Stock at an exercise price equal to $7.438 per share. The options to
purchase 75,000 shares of Common Stock granted to



-14-


Mr. Bollon vest 50% on each of the first and second anniversaries of the date of
grant. The exercise price of each share underlying all the above options is
equal to the fair market value of the Common Stock on the date of grant. See
"Employment Contracts and Termination of Employment and Change-In-Control
Arrangements."


THE AUDIT COMMITTEE REPORT

The Audit Committee currently consists of three members. All the
members of the Audit Committee are independent (as defined in Rule 4200 (a) (15)
of the National Association of Securities Dealers' listing standards). A copy of
the written charter for the Audit Committee adopted by the Board of Directors on
June 4, 2000 is attached hereto as Appendix A.

The independent auditor of the Company during the fiscal year ended
December 31, 2000 was Richard A. Eisner & Company, LLP. In connection with the
audited financial statements contained in our 2000 Annual Report on Form 10-K,
the Audit Committee:

- reviewed and discussed the audited financial statements with
management;

- discussed with our independent auditors, the materials
required to be discussed by Statement on Auditing Standards
No. 61, or SAS 61;

- reviewed the written disclosures and the letter from our
independent auditors required by Independence Standards Board
No. 1 and discussed with our independent auditors their
independence;

- considered whether the non-audit services provided to the
Company by our independent auditors are consistent with our
independent auditor's independence; and

- based on the foregoing review and discussion, recommended to
our Board of Directors that the audited financial statements
be included in our 2000 Annual Report on Form 10-K.

THE AUDIT COMMITTEE

Ira J. Gelb M.D.
Irwin C. Gerson
Walter M. Lovenberg, Ph.D.





-15-


COMPENSATION COMMITTEE REPORT

The Company strives to apply a uniform philosophy to compensation for
all of its employees, including the members of its senior management. This
philosophy is based on the premise that the achievements of the Company result
from the combined and coordinated efforts of all employees working toward common
goals and objectives.

The goals of the Company's compensation program are to align
remuneration with business objectives and performance, and to enable the Company
to retain and competitively reward officers who contribute to the long-term
success of the Company. The Company's compensation program for officers is based
on the following principles, which are applicable to compensation decisions for
all employees of the Company. The Company attempts to pay its officers
competitively in order that it will be able to retain the most capable people in
the industry. Information with respect to levels of compensation being paid by
comparable companies is obtained from various publications and surveys.

During the last fiscal year, the compensation of officers consisted
principally of salary. Salary levels have been set based upon historical levels,
amounts being paid by comparable companies and performance.

1992 Stock Option Plan

In October 1992, the Board of Directors of the Company adopted the
Cytoclonal Pharmaceutics Inc. 1992 Stock Option Plan (the "1992 Plan") which
provides for the awarding of incentive stock options and nonqualified stock
options for the Company's Common Stock to selected key employees, directors,
consultants and advisors of the Company. The 1992 Plan authorizes the awarding
of up to an aggregate of 520,000 stock options for the same number of shares of
the Company's Common Stock in the aggregate. The awards under the 1992 Plan are
subject to restrictions on transferability, are forfeitable in certain
circumstances and are exercisable at such time or times and during such period
as shall be set forth in the option agreement evidencing such option. The
Company registered the shares of Common Stock issuable under the 1992 Plan with
the Commission on a Registration Statement on Form S-8 pursuant to the
Securities Act of 1933, as amended (the "Act"). As of March 23, 2001, options to
purchase 239,000 shares of the Company's common stock have been exercised, no
shares are available for future grant and options to purchase 281,000 shares of
common stock remain outstanding under the 1992 Plan. The exercise price of such
options range from $1.65 to $5.00 per share.

1996 Stock Option Plan

In April 1996, the Board of Directors adopted the 1996 Stock Option
Plan (the "1996 Plan") which provided for the awarding of incentive and
nonqualified stock options to selected key employees, directors, consultants and
advisors to the Company to purchase 750,000 shares of the Company's Common
Stock. At an adjournment of the 1998 Annual Stockholder Meeting, the Company's
stockholders approved amending the 1996 Plan to increase the number of options
available for grant to 1,500,000 for the same number of shares of the Company's
Common Stock. The awards under the 1996 Plan are subject to restrictions on
transferability, are forfeitable in certain circumstances and are exercisable at
such time or times and during such period as shall be set forth in the option
agreement evidencing such option. The Company registered the shares of Common
Stock issuable under the 1996 Plan with the Commission on a Registration
Statement on Form S-8 pursuant to the Act. As of March 23, 2001, no options were
available for future grant, options to purchase 37,400 shares of Common Stock
had been exercised and options to purchase 1,462,600 shares remain outstanding
under the 1996 Plan. The exercise prices of such options granted range from
$2.25 to $8.375 per share.

2000 Stock Option Plan

In January 2000, the Board of Directors adopted the 2000 Stock Option
Plan (the "2000 Plan") which provides for the awarding of incentive stock
options and nonqualified stock options to selected key employees, directors,
consultants and advisors of the Company. The 2000 Plan authorizes the awarding
of up to an aggregate of 1,500,000 stock options for the same number of shares
of the Company's Common Stock in the aggregate. The awards under



-16-



the 2000 Plan are subject to restrictions on transferability, are forfeitable in
certain circumstances and are exercisable at such time or times and during such
period as shall be set forth in the option agreement evidencing such option. As
of March 23, 2001, options to purchase 1,063,000 shares of the Company's Common
Stock have been granted and 437,000 shares were available for future grants. The
exercise prices of options granted under such plan range from $6.75 to $9.875.

In consideration for his services as the Company's President and Chief
Executive Officer for the fiscal year ended December 31, 2000, Dr. Arthur P.
Bollon received compensation consisting of $220,769, a car allowance of $6,000
and incentive stock options to purchase 75,000 of the Company's common stock at
an exercise price of $7.438 per share. As a founder and executive officer of the
Company, Dr. Bollon's scientific expertise, managerial efforts, ingenuity and
leadership are a vital factor to the Company's past and future success,
including developing the Scientific Advisory Board, improving the Company's
financial position, hiring key personnel and furthering the progress of the
Company's technology.



THE COMPENSATION COMMITTEE

Gary E. Frashier
Robert J. Easton
Ira J. Gelb, M.D.
Irwin C. Gerson

CERTAIN BUSINESS RELATIONSHIPS:


In 2000 Roan/Meyers Associates, L.P. received $339,000 in reimburseable
expenses related to the redemption of our Class C and D warrants. In addition,
the Company paid solicitation fees of approximately $1,921,000, which was
charged to additional paid-in-capital in connection with the redemption of the
Class C and D warrants.

In December 2000, we entered in to an agreement with Easton Associates
L.L.C., a company founded by our director Robert J. Easton, for strategy and
market planning services at an annual fee of $125,000.



-17-


PERFORMANCE GRAPH

The graph below compares the five-year cumulative stockholder total
return based upon an initial $100 investment (assuming the reinvestment of
dividends) for the Company's shares of Common Stock on December 31, 1995 with
the comparable return for the Nasdaq Market Index and a peer issuer index
selected on an industry basis. The peer group index includes 227
biopharmaceutical companies whose common stock has been registered under Section
12 of the Securities Exchange Act of 1934 for at least the time frame set forth
in the graph.

The total stockholder returns depicted in the graph are not necessarily
indicative of future performance. The Performance Graph and related disclosure
shall not be deemed to be incorporated by reference in any filing by the Company
under the Securities Act of 1933 or the Securities Exchange Act of 1934, except
to the extent that the Company specifically incorporates the graph and such
disclosure by reference.

COMPARE 5-YEAR CUMULATIVE TOTAL RETURN
AMONG CYTOCLONAL PHARMACEUTICS INC.,
NASDAQ MARKET INDEX AND SIC CODE INDEX



[PERFORMANCE GRAPH]



CUMULATIVE TOTAL RETURN OF
COMPANY, NASDAQ MARKET INDEX AND PEER GROUP




COMPANY/MARKET/INDEX FISCAL YEAR ENDED
- -------------------- -------------------------------------------------------------------------

12/31/95 12/31/96 12/31/97 12/31/98 12/31/99 12/31/00
-------- -------- -------- -------- -------- --------


Cytoclonal Pharmaceutics 100.00 50.00 161.76 161.76 176.47 173.53
Inc.

Nasdaq Market Index 100.00 124.27 152.00 214.39 378.12 237.66

Peer Group (227 100.00 123.41 179.31 254.34 228.82 302.56
biopharmaceutical
companies)




-18-



PROPOSAL 2

RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

The Board of Directors has appointed Ernst & Young LLP, effective April
23, 2001, as the Company's independent auditors for the fiscal year ending
December 31, 2001, to replace Richard A. Eisner & Company, LLP ("Eisner"), the
Company's prior independent auditors. The decision to change auditors was
approved by the Audit Committee and the full Board of Directors. The Board of
Directors has further directed that management submit the selection of
independent auditors for ratification by the stockholders at the Annual Meeting.
Representatives of Ernst & Young LLP are expected to be present at the Annual
Meeting, will have an opportunity to make a statement if they so desire and will
be available to respond to appropriate questions. Representatives of Eisner are
not expected to attend the Annual Meeting.

Eisner's reports on the financial statements of the Company for the
fiscal years ended December 31, 2000 and 1999 (the two most recent audited
fiscal years) contain no adverse opinion or disclaimer of opinion and were not
qualified or modified as to uncertainty, audit scope or accounting principles.
During the fiscal years ended December 31, 2000 and 1999 (the two most recent
audited fiscal years) and subsequent interim periods through April 26, 2001,
there have been no disagreements between the Company and Eisner on any matter of
accounting principles or practices, financial statement disclosure, or auditing
scope or procedure, which disagreements, if not resolved to the satisfaction of
Eisner, would have caused them to make a reference to the subject matter of the
disagreement in Eisner's reports on the Company's financial statements for such
periods. During the fiscal years ended December 31, 2000 and 1999 (the two most
recent audited fiscal years) and subsequent interim periods through April 26,
2001, there have been no reportable events as defined in Item 304(a)(1)(v) of
Regulation S-K.

During the fiscal years ended December 31, 2000 and 1999 (the two most
recent audited fiscal years) and subsequent interim periods prior to the
Company's engagement of Ernst & Young LLP, the Company did not consult with
Ernst & Young LLP regarding (i) the application of accounting principles to a
specified transaction, either completed or proposed, or the type of audit
opinion that might be rendered by Ernst & Young LLP, or (ii) any other matter
that was either the subject of a disagreement, as that term is defined in Item
304(a)(1)(iv) of Regulation S-K and the related instructions to Item 304 of
Regulation S-K, or a reportable event, as that term is defined in Item
304(a)(1)(v) of Regulation S-K.

AUDIT FEES

The aggregate fees billed by Eisner for professional services rendered
for the audit of the Company's annual financial statements for the year ended
December 31, 2000 were $97,700.

FINANCIAL INFORMATION SYSTEMS DESIGN AND IMPLEMENTATION FEES

There were no financial information systems design and implementation
fees billed by Eisner for the year ended December 31, 2000.

OTHER FEES

Eisner provided professional services to the Company in the fiscal year
ended December 31, 2000 in connection with the Company's tax returns, a response
letter to the Commission and review of other filings with the Commission, the
fees for which were $32,400. After consideration of the issue, the Audit
Committee determined that Eisner's provision of the foregoing services is
compatible with maintaining Eisner's independence as the Company's independent
auditor.

Stockholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's By-laws or
otherwise. However, the Board is submitting the selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice. If
the stockholders fail to ratify the




-19-



selection, the Audit Committee and the Board will reconsider whether or not to
retain that firm. Even if the selection is ratified, the Audit Committee and the
Board in their discretion may direct the appointment of different independent
auditors at any time during the year if they determine that such a change would
be in the best interests of the Company and its stockholders.

The affirmative vote of the holders of a majority of the shares present
in person or represented by proxy and entitled to vote at the Annual Meeting
will be required to ratify the selection of Ernst & Young LLP. Abstentions will
be counted toward the tabulation of votes cast on proposals presented to the
stockholders and will have the same effect as negative votes. Broker non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.


THE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS A VOTE "FOR" PROPOSAL 2.
PROXIES SOLICITED BY THE BOARD OF DIRECTORS WILL BE SO VOTED UNLESS STOCKHOLDERS
SPECIFY OTHERWISE IN THEIR PROXIES.





















-20-


PROPOSAL 3

AMENDMENT OF THE COMPANY'S 2000 STOCK OPTION PLAN


PROPOSED AMENDMENTS

INTRODUCTION

At the Annual Meeting, the Company's stockholders will be asked to
approve amendments to the 2000 Plan to (i) increase the number of shares of
Common Stock reserved for issuance thereunder from 1,500,00 to 2,750,000; (ii)
change the vesting period for options, such that one-third of the options vest
on the first anniversary of the date of grant, one-third vest on the second
anniversary of the date of grant and the final third vest on the third
anniversary of the date of grant, rather than half of the options vesting on the
first anniversary of the date of grant and the second half of the options
vesting on the second anniversary of the date of grant; and (iii) permit new
option holders and existing option holders to exercise their options by cashless
exercise of their options or other means.

The Board of Directors believes that the availability of stock
incentives is an important factor in the Company's ability to not only attract
and maintain key employees, directors, officers and consultants but also to give
them an added incentive to exert their best efforts on behalf of the Company.
The Board of Directors believes that the proposed amendments are needed to
provide option grants to key persons during the next two to three years.

The following is a summary of the amendments to the 2000 Plan, which is
qualified in its entirety by reference to the text of the Cytoclonal
Pharmaceutics Inc. Amended and Restated 2000 Option Plan (the "Amended and
Restated 2000 Plan"). The Amended and Restated 2000 Plan is attached as Appendix
B to this Proxy Statement and incorporated herein by reference.

SHARES AVAILABLE

The 2000 Plan provides for the grant of incentive stock options
("ISOs") and nonqualified stock options ("NQSOs") in compliance with the
Internal Revenue Code of 1986, as amended (the "Code") to employees
(approximately 34 as of the Record Date), officers (five as of the Record Date)
and directors (seven as of the Record Date) of, and consultants and advisors
(approximately 18 as of the Record Date) to, the Company who are expected to
contribute to the Company's future growth and success. As of the date of this
Proxy Statement, of the 1,500,000 shares of Common Stock reserved for issuance
upon the exercise of options under the 2000 Plan, options to purchase 1,063,000
shares of the Company's common stock have been granted.

EXERCISE OF OPTIONS

The Committee determines when options granted under the 2000 Plan may
be exercisable. Under the current 2000 Plan, an option is exercisable 50% on the
first anniversary of the date of grant and the remaining 50% on the second
anniversary of the date of grant. Under the proposed amendments to the 2000
Plan, an ISO would be exercisable one-third on the first anniversary of the date
of grant, one-third on the second anniversary of the date of grant and the
remaining one-third on the third anniversary of the date of grant.

Under the current 2000 Plan, an option may be exercised by (i)
notifying the Company in a writing which specifies the number of full shares of
Common Stock to be purchased and (ii) tendering to the Company payment of the
purchase price in cash or by check. Under the proposed amendments to the 2000
Plan, unless otherwise provided in the stock option agreement, the purchase
price of shares purchased upon exercise of an option may be paid by cash, by
certified or cashier's check, or by any other means authorized by the Committee
and permitted by the Delaware General Corporation Law, including surrender of
shares of the Company's Common Stock having a Market Price equal to the exercise
price.



-21-


DESCRIPTION OF THE 2000 PLAN

The 2000 Plan provides that the exercise prices of options shall be
determined by the Compensation Committee at the time of grant. However, in the
case of ISOs, the exercise price shall be no less than the fair market value of
the Company's Common Stock on the date of grant (110% in the case of
stockholders owning more than 10% of the Company's voting securities), and shall
expire no later than the tenth (10th) anniversary of the date of grant (the
fifth (5th) anniversary in the case of stockholders owning more than 10% of the
Company's voting securities). Generally, ISOs, to the extent such options are
vested, may be exercised within a period of (i) three (3) months in the event an
optionee ceases to be an employee of the Company, (ii) three (3) months if the
optionee dies while in the employ of the Company and (iii) one (1) year if the
optionee becomes disabled within the meaning of Section 22(e)(3) of the Code.
Notwithstanding, an NQSO, to the extent such options are vested, will be
exercisable within a period of (i) three (3) months if the optionee dies while
in the employ of the Company and (ii) one (1) year if the optionee becomes
disabled within the meaning of Section 22(e)(3) of the Code. Pursuant to the
2000 Plan and in compliance with the Code, to the extent that the aggregate fair
market value, determined by the date or dates of grant, for which ISOs are first
exercisable by an optionee during any calendar year exceeds $100,000, such
options shall be treated as NQSOs.

CERTAIN FEDERAL TAX INFORMATION

The following is a summary of the U.S. federal income tax consequences
that generally will arise with respect to options granted pursuant to the 2000
Plan and with respect to the shares of Common Stock of the Company issuable upon
the exercise thereof.

ISOs

In general, an optionee will not recognize compensation income upon the
grant or exercise of an ISO. The basis of shares transferred to an optionee
pursuant to the exercise of an ISO is the price paid for such shares (i.e., the
exercise price). Instead, an optionee will recognize taxable income upon the
sale of Common Stock issuable upon the exercise of an ISO. Notwithstanding, the
exercise of an ISO may subject the optionee to the alternative minimum tax
because the difference between the exercise price and the fair market value of
the stock on the date of exercise is alternative minimum taxable income.

In general, the tax consequences of selling Common Stock issuable upon
the exercise of an ISO will vary with the length of time that the optionee holds
such Common Stock prior to such sale. An optionee will recognize long-term
capital gain or loss equal to the difference between the sale price of the
Common Stock and the exercise price if the optionee sells the Common Stock after
having had owned it for at least (i) two (2) years from the date the option was
granted (the "Grant Date") and (ii) one (1) year from the date the option was
exercised (the "Exercise Date").

However, an optionee will recognize compensation income in the year of
the sale if the optionee sells the Common Stock issuable upon the exercise of an
ISO prior to having owned it for less than (i) two (2) years from the Grant Date
or (ii) one (1) year from the Exercise Date. Such a transfer is referred to as
a "Disqualifying Disposition." The amount of compensation income equals the
difference between the option's exercise price and the stock's fair market
value at the time of exercise (i.e., the bargain purchase element). This
compensation income is added to the basis of the stock for purposes of
determining the gain on the sale of the ISO stock. If the ISO stock is sold in
a transaction in which a loss (if sustained) would be recognized, compensation
income is limited to the excess, if any, of the amount realized on the sale
over the adjusted basis of the ISO stock (i.e., the exercise price, with
adjustments, if any).

NQSOs

As in the case of ISOs, an optionee will recognize no income tax upon
the grant of an NQSO. Unlike an ISO, however, an optionee exercising an NQSO
will recognize ordinary income equal to the excess of the fair market value of
the Company's Common Stock on the Exercise Date over the exercise price.



-22-


With respect to the Common Stock issuable upon the exercise of an NQSO,
a optionee generally will have a tax basis equal to the fair market value of the
stock on the Exercise Date. Upon the subsequent sale of Common Stock issuable
upon the exercise of an NQSO, an optionee will recognize a capital gain or loss,
assuming the stock was a capital asset in the optionee's hands, equal to the
difference between the tax basis of the Common Stock and the amount realized
upon disposition. If the optionee has held the stock for more than one (1) year,
the gain or loss will be long-term capital gain or loss.

TAX CONSEQUENCES TO THE COMPANY

The grant of ISOs and NQSOs under the 2000 Plan will have no tax
consequences to the Company. Furthermore, in the case of ISOs, the Company will
not experience any tax consequences from the exercise of ISOs granted under the
2000 Plan unless there is a Disqualifying Disposition. The Company generally
will be entitled to a business-expense deduction equal to the compensation
income recognized by the optionee from a Disqualifying Disposition of an ISO or
from the exercise of an NQSO; provided, however, that such deduction will be
subject to the limitation of Code Section 162(m).

THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" THE AMENDMENTS TO THE
COMPANY'S 2000 PLAN AS DESCRIBED ABOVE AND THE RESERVATION OF 1,250,000
ADDITIONAL SHARES OF COMMON STOCK FOR ISSUANCE THEREUNDER. PROXIES SOLICITED BY
THE BOARD OF DIRECTORS WILL BE SO VOTED UNLESS STOCKHOLDERS SPECIFY OTHERWISE IN
THEIR PROXIES.












-23-


PROPOSAL 4

OTHER BUSINESS

The Board of Directors knows of no business which will be presented at
the Annual Meeting other than as stated herein and in the Notice of Meeting
attached hereto. If, however, other matters are properly brought before the
Annual Meeting, it is the intention of the persons named in the accompanying
form of proxy to vote the shares represented thereby on such matters as directed
by the Board of Directors.

The management of the Company does not know of any matters other than
those stated in this Proxy Statement which are to be presented for action at the
Annual Meeting. If any other matters should properly come before the Annual
Meeting, it is intended that proxies in the accompanying form will be voted on
any such matters in accordance with the judgment of the persons voting such
proxies.

STOCKHOLDER PROPOSALS TO BE PRESENTED
AT THE NEXT ANNUAL MEETING

Stockholder Proposals. Proposals of stockholders intended to be
presented at the Company's 2002 Annual Stockholder Meeting (i) must be received
by the Company at its offices no later than January 31, 2002, 90 days preceding
the one year anniversary of the Mailing Date, (ii) may not exceed 500 words and
(iii) must otherwise satisfy the conditions established by the Commission for
stockholder proposals to be included in the Company's Proxy Statement for that
meeting.

Discretionary Proposals. Stockholders intending to commence their own
proxy solicitations and present proposals from the floor of the 2002 Annual
Stockholder Meeting in compliance with Rule 14a-4 promulgated under the Exchange
Act of 1934, as amended, must notify the Company before March 18, 2002, 45 days
preceding the one year anniversary of the Mailing Date, of such intentions.
After such date, the Company's proxy in connection with the 2002 Annual
Stockholder Meeting may confer discretionary authority on the Board to vote.

GENERAL

The Company will bear the cost of preparing, assembling and mailing the
Proxy, Proxy Statement and other material which may be sent to the stockholders
in connection with this solicitation. In addition to the solicitation of proxies
by use of the mails, officers and regular employees may solicit the return of
proxies. The Company may reimburse persons holding stock in their names or in
the names of other nominees for their expense in sending proxies and proxy
material to principals. In addition, American Stock Transfer & Trust Company,
6201 15th Avenue, Brooklyn, New York 11219, the Company's transfer agent, has
been engaged to mail proxies on behalf of the Company. Proxies may be solicited
by mail, personal interview, telephone and telegraph.

THE COMPANY WILL PROVIDE WITHOUT CHARGE TO EACH PERSON BEING SOLICITED
BY THIS PROXY STATEMENT, UPON THE WRITTEN REQUEST OF ANY SUCH PERSON, A COPY OF
THE COMPANY'S ANNUAL REPORT ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 2000,
AS FILED WITH THE COMMISSION, INCLUDING THE FINANCIAL STATEMENTS AND THE
SCHEDULES THERETO. ALL SUCH REQUESTS SHOULD BE DIRECTED TO MR. DANIEL
SHUSTERMAN, SECRETARY, CYTOCLONAL PHARMACEUTICS INC., 2110 RESEARCH ROW, SUITE
621, DALLAS, TEXAS 75235.

By Order of the Board of Directors


Daniel Shusterman, J.D., Secretary




-24-


APPENDIX A


AUDIT COMMITTEE CHARTER

The members of the Audit Committee shall be appointed by the Board of Directors
to assist the Board in monitoring (1) the integrity of the Company's financial
reporting process including its internal controls regarding financial reporting,
(2) the compliance by the Company with legal and regulatory requirements, (3)
the independence and performance of the Company's internal and external auditors
and (4) provide an avenue of communication among the independent auditors,
management, the internal auditing department and the Board of Directors.

The number of members of the Audit Committee and their independence and
experience requirements shall meet the National Association of Securities
Dealers, Inc. ("NASD") and Securities and Exchange Commission requirements.

The Audit Committee shall have the authority to retain special legal, accounting
or other consultants to advise the Committee. The Audit Committee may request
any officer or employee of the Company or the Company's outside counsel or
independent auditor to attend a meeting of the Committee or to meet with any
members of, or consultants to, the Committee.

The Audit Committee shall:

1. Review and reassess the adequacy of this Charter annually and submit it
to the Board for approval.

2. Review the annual audited financial statements with management,
including major issues regarding accounting and auditing principles and
practices as well as the adequacy of internal controls that could
significantly affect the Company's financial statements.

3. Review an analysis prepared by management and the independent auditor
of significant financial reporting issues and judgments made in
connection with the preparation of the Company's financial statements.

4. In consultation with management, the independent auditors, and the
internal auditors, consider the integrity of the Company's financial
reporting processes and controls.

5. Review with management and the independent auditor the Company's
quarterly financial statements prior to the release of quarterly
earnings.

6. Meet with management to review the Company's major financial risk
exposures and the steps management has taken to monitor and control
such exposures.

7. Review major changes to the Company's accounting principles and
practices taking into consideration the views of the independent
auditor, internal auditors or management.

8. Recommend to the Board the appointment of the independent auditor.

9. Approve the fees to be paid to the independent auditor.

10. Receive periodic reports from the independent auditor regarding the
auditor's independence, discuss such reports with the auditor, and if
so determined by the Audit Committee, recommend that the Board take
appropriate action to assure the independence of the auditor.

11. Evaluate the performance of the independent auditor and, if so
determined by the Audit Committee, recommend that the Board replace the
independent auditor.

12. Review the appointment and replacement of the senior internal auditing
executive.



A-1



13. Review the significant reports to management prepared by the internal
auditing department and management's responses.

14. Meet with the independent auditor prior to the audit to review the
planning and staffing of the audit.

15. Obtain from the independent auditor an understanding of whether there
are any indications that Section 10A of the Private Securities
Litigation Reform Act of 1995 is applicable and consult counsel if
necessary.

16. Obtain reports from management, the Company's senior internal auditing
executive and the independent auditor that the Company's
subsidiary/foreign affiliated entities, if any, are in conformity with
applicable legal requirements and the Company's Code of Conduct.

17. Discuss with the independent auditor the matters required to be
discussed by Statement on Auditing Standards No. 61 relating to the
conduct of the audit.

18. Review with the independent auditor any problems or difficulties the
auditor may have encountered and any management letter provided by the
auditor and the Company's response to that letter. Such review should
include a discussion of any difficulties encountered in the course of
the audit work, including any restrictions on the scope of activities
or access to required information.

19. Prepare the report required by the rules of the Securities and Exchange
Commission to be included in the Company's annual proxy statement.

20. Advise the Board with respect to the Company's policies and procedures
regarding compliance with applicable laws and regulations and with the
Company's Code of Conduct.

21. Review with the Company's General Counsel legal matters that may have a
material impact on the financial statements, the Company's compliance
policies and any material reports or inquiries received from regulators
or governmental agencies.

22. Meet at least annually with the chief financial officer, the senior
internal auditing executive and the independent auditor in separate
executive sessions.

23. Establish, review, and update periodically a Code of Ethical Conduct
and ensure that management has established a system to enforce the
code.

24. Annually review policies and procedures as well as internal audit
results associated with directors' and officers expense accounts and
perquisites.

25. Annually review director and officer related party transactions and
potential conflicts of interest.

26. Perform any other activities consistent with this Charter, as the
Committee or Board deems necessary or appropriate.

While the Audit Committee has the responsibilities and powers set forth in this
Charter, it is not the duty of the Audit Committee to plan or conduct audits or
to determine that the Company's financial statements are complete and accurate
and are in accordance with generally accepted accounting principles; this is the
responsibility of management and upon completion of the audit by the independent
auditor, subject to their findings, they render their report on the financial
statements. Nor is it the duty of the Audit Committee to conduct investigations,
to resolve disagreements, if any, between management and the independent auditor
or to assure compliance with laws and regulations and the Company's Code of
Conduct; this is the responsibility of the Board.





A-2


APPENDIX B

CYTOCLONAL PHARMACEUTICS INC.

AMENDED AND RESTATED

2000 STOCK OPTION PLAN

(Proposed changes indicated in italics)

1. Purpose; Types of Awards: Construction

The purpose of the Cytoclonal Pharmaceutics Inc. Amended and Restated
2000 Stock Option Plan (the "PLAN") is to provide incentives to directors,
officers, employees, independent contractors, advisers and consultants of
Cytoclonal Pharmaceutics Inc. (the "COMPANY") or any subsidiary of the Company
which now exists or hereafter is organized or acquired by the Company, to
acquire a proprietary interest in the Company, to increase their efforts on
behalf of the Company and to promote the success of the Company's business. The
Plan is intended to permit the Committee (as defined in Section 3 hereof) to
issue options totaling 2,750,000 shares of the Company's common stock to
directors, officers, employees, independent contractors, advisers and
consultants of the Company. The Committee may grant options which shall
constitute either "nonqualified stock options" ("NON-QUALIFIED STOCK OPTIONS")
or "incentive stock options" ("INCENTIVE STOCK OPTIONS" or "ISO") within the
meaning of Section 422 of the Internal Revenue Code of 1986, as amended (the
"Code").


2. Definitions

As used in this Plan, the following words and phrases shall have the
meanings indicated:

(a) "Board" shall mean the Board of Directors of the Company.

(b) "Common Stock" shall mean shares of common stock, par value $.01
per share, of the Company.

(c) "Disability" shall have the meaning set forth in Section 22(e)(3)
of the Code.

(d) "Fair Market Value" per share as of a particular date shall mean
the value determined by the Committee in its discretion; provided, however, that
in the event that there is a public market for the Common Stock, the fair market
value is, if available, (i) the closing price of the Common Stock as of the date
of grant as reported (in descending order of priority) on (A) a national
securities exchange listing the Common Stock, (B) the NASDAQ Stock Market, (C) a
national automated quotation system with daily trading volume in the Common
Stock in excess of 10,000 shares, or (D) a regional securities exchange listing
the Common Stock, or (ii) the average of the closing bid and asked prices of the
Common Stock for the previous five trading days.

(e) "Option" or "Options" shall mean a grant to an Optionee of an
option or options to purchase shares of Common Stock. Options granted by the
Committee pursuant to the Plan shall constitute either Nonqualified Stock
Options or Incentive Stock Options, as determined by the Committee.

(f) "Parent Corporation" shall mean any corporation (other than the
Company) in an unbroken chain of corporations ending with the employer
corporation if, at the time of granting an Option, each of the corporations
other than the employer corporation owns stock possessing fifty percent (50%) or
more of the total combined voting power of all classes of stock in one of the
other corporations in such chain.



B-1


(g) "Subsidiary Corporation" shall mean any corporation (other than the
Company) in an unbroken chain of corporations beginning with the employer
corporation if, at the time of granting an Option, each of the corporations
other than the last corporation in the unbroken chain owns stock possessing
fifty percent (50%) or more of the total combined voting power of all classes of
stock in one of the other corporations in such chain.

(h) "Ten Percent Stockholder" shall mean an Optionee who, at the time
an Incentive Stock Option is granted, owns stock possessing more than ten
percent (10%) of the total combined voting power of all classes of stock of the
Company or of its Parent or Subsidiary Corporations.

3. Administration

(a) The Plan shall be administered by a committee (the "COMMITTEE")
established by the Board, the composition of which shall at all times consist of
two (2) or more individuals who are each members of the Board. If no Committee
is appointed by the Board, the functions of the Committee shall be carried out
by the Board, provided, however, that if at any time the Corporation has
outstanding a class of equity securities required to be registered under Section
12 of the Securities Exchange Act of 1934, as amended (the "1934 ACT"), the
Corporation shall use reasonable efforts to grant, designate or amend any
Options hereunder through a committee consisting solely of two or more persons,
each of whom shall qualify as (i) a "Non-Employee Director", as that term is
defined in subparagraph (b)(3)(i) of Rule 16b-3 ("RULE 16b-3") promulgated under
the 1934 Act, and (ii) an "outside director", within the meaning of Section
162(m) of the Code.

(b) The Committee shall choose one of its members as Chairman and shall
hold meetings at such times and places as it shall deem advisable. A majority of
the members of the Committee shall constitute a quorum and any action may be
taken by a majority of those present and voting at any meeting. Any action may
also be taken without the necessity of a meeting by a written instrument signed
by all members of the Committee. The decision of the Committee as to all
questions of interpretation and application of the Plan shall be final, binding
and conclusive on all persons. The Committee shall have the authority to adopt,
amend and rescind such rules and regulations as, in its opinion, may be
advisable in the administration of the Plan. The Committee may correct any
defect or supply any omission or reconcile any inconsistency in the Plan or in
any Option Agreement (as defined in Section 8) in the manner and to the extent
it shall deem expedient to carry the Plan into effect and shall be the sole and
final judge of such expediency. No Committee member shall be liable for any
action or determination made in good faith.

(c) The Committee shall have the authority in its discretion, subject
to and not inconsistent with the express provisions of the Plan, to administer
the Plan and to exercise all the powers and authorities either specifically
granted to it under the Plan or necessary or advisable in the administration of
the Plan, including, without limitation, the authority to grant Options; to
determine the purchase price of the shares of Common Stock covered by each
Option (the "OPTION PRICE"); to determine the persons to whom, and the time or
times at which awards shall be granted, (such persons are referred to herein as
"OPTIONEES"); to determine the number of shares to be covered by each award; to
interpret the Plan; to prescribe, amend and rescind rules and regulations
relating to the Plan; to determine the terms and provisions of the agreements
(which need not be identical) entered into in connection with awards granted
under the Plan; to cancel or suspend awards, as necessary; and to make all other
determinations deemed necessary or advisable for the administration of the Plan.
The Committee may delegate to one or more of its members or to one or more
agents such administrative duties as it may deem advisable, provided, however,
that if at any time the Corporation has outstanding a class of equity securities
required to be registered under Section 12 of the 1934 Act, the Committee may
not delegate any of its responsibilities hereunder to any person who is not both
a "Non-Employee Director", as that term is defined in subparagraph (b)(3)(i) of
Rule 16b-3, and an "outside director", within the meaning of Section 162(m) of
the Code. The Committee or any person to whom it has delegated duties as
aforesaid may employ one or more persons to render advice with respect to any
responsibility the Committee or such person may have under the Plan. All
decisions, determinations and interpretations of the Committee shall be final
and binding on all Optionees.

(d) The Board shall fill all vacancies, however caused.

(e) No member of the Board or Committee shall be liable for any action
taken or determination made in good faith with respect to the Plan or any award
granted hereunder.



B-2
4. Eligibility

(a) Awards may be granted to directors, officers, employees,
independent contractors, advisers and consultants of the Company. In determining
the persons to whom awards shall be granted and the number of shares to be
covered by each award, the Committee shall take into account the duties of the
respective persons, their present and potential contributions to the success of
the Company and such other factors as the Committee shall deem relevant in
connection with accomplishing the purposes of the Plan.

(b) Options designated as ISOs may be granted only to officers and
other employees of the Company or any "subsidiary corporation" as defined in
Section 424 of the Code. Non-Qualified Stock Options may be granted to any
officer, employee, director, independent contractor, adviser, or consultant of
the Company or of any Subsidiary Corporation. Non-Qualified Stock Options may be
granted to an individual in connection with the hiring or engagement of the
individual prior to the date that the individual first performs services for the
Company or any Subsidiary Corporation.

5. Common Stock Subject to the Plan

(a) The maximum number of shares of Common Stock reserved for the grant
of Options shall be 2,750,000. Such shares may, in whole or in part, be
authorized but unissued shares or shares that shall have been or may be
reacquired by the Company.

(b) If any outstanding award under the Plan should, for any reason
expire, be canceled or be terminated, without having been exercised in full, the
shares of Common Stock allocable to the unexercised, canceled or terminated
portion of such award shall (unless the Plan shall have been terminated) become
available for subsequent grants of awards under the Plan.

(c) Stock issuable upon exercise of an option granted under the Plan
may be subject to such restrictions on transfer, repurchase rights or other
restrictions as shall be determined by the Committee.

6. Incentive Stock Options

Options granted pursuant to this Section 6 are intended to
constitute Incentive Stock Options and shall be subject to the following special
terms and conditions, in addition to the general terms and conditions specified
in Section 8 hereof.

(a) Vesting. Options granted shall vest one-third on the first
anniversary of the date of grant, one-third on the second anniversary of the
date of grant and one-third on the third anniversary of the date of grant and
the exercise prices of such options shall be determined by the Compensation
Committee at the time of grant.

(b) Value of Shares. The aggregate Fair Market Value (determined as of
the date that Incentive Stock Options are granted) of the shares of Common Stock
with respect to which Incentive Stock Options granted under this Plan and all
other option plans of the Company and any Parent or Subsidiary Corporation that
become exercisable for the first time by an Optionee during any calendar year
shall not exceed $100,000.

(c) Ten Percent Stockholders. In the case of an Incentive Stock Option
granted to a Ten Percent Stockholder, (i) the Option Price shall not be less
than one hundred ten percent (110%) of the Fair Market Value of the shares of
Common Stock on the date of grant of such Incentive Stock Option, and (ii) the
exercise period shall not exceed five (5) years from the date of grant of such
Incentive Stock Option.


B-3


7. Nonqualified Stock Options

Options granted pursuant to this Section 7 are intended to
constitute Non-Qualified Stock Options and shall be subject only to the general
terms and conditions specified in Section 8 hereof.

8. Terms and Conditions of Options

Each Option granted pursuant to the Plan shall be evidenced by
a written agreement between the Company and the Optionee in such form as the
Committee shall from time to time approve (the "OPTION AGREEMENT"), which Option
Agreement shall be subject to and set forth the following terms and conditions:

(a) Number of Shares. Each Option Agreement shall state the number of
shares of Common Stock to which the option relates.

(b) Type of Option. Each Option Agreement shall specifically state
whether the Option constitutes a Non-Qualified Stock Option or an Incentive
Stock Option.

(c) Option Price. The option price or prices of shares of the Company's
Common Stock for options designated as Non-Qualified Stock Options shall be as
determined by the Committee, but in no event shall the option price be less than
the minimum legal consideration required therefor under the laws of the State of
Delaware or the laws of any jurisdiction in which the Company or its successors
in interest may be organized. The option price or prices of shares of the
Company's Common Stock for ISOs shall be the Fair Market Value of such Common
Stock at the time the option is granted as determined by the Committee.

(d) Method and Time of Payment. Each Option Agreement shall require
that the Option Price be paid in full, at the time of exercise of an Option, in
cash, by certified or cashier's check, or by any other means authorized by the
Committee and permitted by the Delaware General Corporation Law, including the
surrender of shares of Common Stock (whether then owned by the Grantee or
issuable upon exercise of the Option) having a Fair Market Value equal to such
Option Price or in a combination of cash and shares of Common Stock.

(e) Term and Exercisability of Options. Except as otherwise provided in
this Section 8 or Section 9 hereof or unless otherwise determined by the
Committee and set forth in the Option Agreement, at the discretion of the
Committee, options may become exercisable in such number of cumulative
installments as the Committee may establish, provided, however, no option may be
exercisable until at least six months and one day from the date of grant.
The Committee, however, shall have the authority to accelerate
the exercisability of any outstanding Option at such time and under such
circumstances as it, in its sole discretion, deems appropriate. Except as
specifically provided in Sections 8(f) and 8(g) hereof, all Options shall expire
ten (10) years from the date of grant of such Option (five (5) years in the case
of an Incentive Stock Option granted to a Ten Percent Stockholder) or on such
earlier date as may be prescribed by the Committee and set forth in the Option
Agreement. An Option may be exercised, as to any or all full shares of Common
Stock as to which the Option has become exercisable, by giving written notice of
such exercise to the Committee or its designated agent; provided, however, that
an Option may not be exercised at any one time as to fewer than 100 shares (or
such number of shares as to which the Option is then exercisable if such number
of shares is less than 100).

(f) Termination of Employment. Except as provided in this Section 8(f)
and in Sections 8(e) and (h) hereof, each Option granted hereunder shall expire,
to the extent not theretofore exercised, three (3) months after the date the
Optionee ceases to be employed by the Company or any of its Parent or Subsidiary
Corporations (or on such other date as may be prescribed by the Committee and
set forth in any Option Agreement).

(g) Death or Disability of Optionee. If an Optionee shall die while
employed by the Company or a Parent or Subsidiary Corporation or if the
Optionee's employment shall terminate by reason of Disability, all Options
theretofore granted to such Optionee (to the extent otherwise exercisable) may,
unless earlier terminated in accordance with their terms, be exercised by the
Optionee or by the Optionee's estate or by a person who acquired the right to
exercise such Options by bequest or inheritance or otherwise by reason of the
death or Disability of the Optionee, at any time within


B-4


three (3) months after the date of death or one (1) year after the date of
Disability of the Optionee; provided, however, that the Committee may, in any
Non-Qualified Stock Option Agreement, extend such period of exercisability. In
the event that an Option granted hereunder shall be exercised by the legal
representatives of a deceased or former Optionee, written notice of such
exercise shall be accompanied by a certified copy of letters testamentary or
equivalent proof of the right of such legal representative to exercise such
option.

(h) Other Provisions. The Option Agreements evidencing Options under
the Plan shall contain such other terms and conditions, not inconsistent with
the Plan, as the Committee may determine.

9. Effect of Certain Changes

(a) If there is any change in the shares of Common Stock through the
declaration of extraordinary dividends, stock dividends, re-capitalization,
stock splits, or combinations or exchanges of such shares, or in the event of a
sale of all or substantially all of the assets of the Company (an "ASSET SALE"),
or the merger or consolidation of the Company with or into another corporation
(a "MERGER"), or in the event of other similar transactions, the Committee shall
promptly make an appropriate adjustment to the number and class of shares of
Common Stock available for awards, to the number of shares covered by
outstanding awards after the effective date of such transaction, and, if
applicable, to the price thereof; provided, however, that any fractional shares
resulting from such adjustment shall be eliminated.

(b) In the event of the dissolution or liquidation of the Company, in
the event of any corporate separation or division, including, but not limited
to, split-up, split-off or spin-off or in the event of other similar
transactions, the Committee may provide that:

i. the Optionee of any Option shall have the right to exercise
such Option; and/or


ii. each Option granted under the Plan shall terminate as of a
date to be fixed by the Committee, and that not be less than thirty (30) days
notice of the date so fixed shall be given to each Optionee, who shall have the
right, during the period of thirty (30) days preceding such termination, to
exercise (to the extent exercisable) with respect to such Option all or any part
of the shares of Common Stock covered thereby.

(c) In the event of an Asset Sale or a Merger, any award then
outstanding may be assumed or an equivalent award may be substituted by such
successor corporation or a parent or subsidiary of such successor corporation.
If such successor corporation does not agree to assume the award or to
substitute an equivalent award, the Board may, in lieu of such assumption or
substitution, provide for the realization of such outstanding award in the
manner set forth in subsections 9(b)(i) or 9(b)(ii) above.

(d) In the event of a change in the Common Stock of the Company as
presently constituted that is limited to a change of all of its authorized
shares of Common Stock into the same number of shares with a different par value
or without par value, the shares resulting from any such change shall be deemed
to be the Common Stock within the meaning of the Plan.

(e) Except as hereinbefore expressly provided in this Section 9, the
Optionee of an award hereunder shall have no rights by reason of any subdivision
or consolidation of shares of stock of any class or the payment of any stock
dividend or any other increase or decrease in the number of shares of stock of
any class or by reason of any dissolution, liquidation, Merger or spin-off of
assets or stock of another company; and any issuance by the Company of shares of
stock of any class, or securities convertible into shares of stock of any class,
shall not affect, and no adjustment by reason thereof shall be made with respect
to, the number or price of shares of Common Stock subject to an award. The grant
of an award pursuant to the Plan shall not affect in any way the right or power
of the Company to make adjustments, reclassifications, reorganizations or
changes of its capital or business structures or to merge or to consolidate or
to dissolve, liquidate or sell, or transfer all or part of its business or
assets or engage in any similar transactions.


B-5
10. Period During Which Options May Be Granted

Awards may be granted pursuant to the Plan from time to time
within a period of ten (10) years from the date the Plan is adopted by the
Board, or the date the Plan is approved by the stockholders of the Company,
whichever is earlier.

11. Nontransferability of Awards

The right of any Optionee to exercise any option granted to
him or her shall not be assignable or transferable by such Optionee otherwise
than by will or the laws of descent and distribution, or pursuant to a domestic
relations order, and any such option shall be exercisable during the lifetime of
such Optionee only by him; provided, however, that the Committee may permit the
further transferability of Non-Qualified Stock Options on a general or specific
basis and may impose conditions and limitations on any permitted transferee. Any
option granted under the Plan shall be null and void and without effect upon the
bankruptcy of the Optionee to whom the option is granted, or upon any attempted
assignment or transfer, except as herein provided, including without limitation
any purported assignment, whether voluntary or by operation of law, pledge,
hypothecation or other disposition, attachment, divorce, except as provided
above with respect to Non-Qualified Stock Options, trustee process or similar
process, whether legal or equitable, upon such option.

12. Beneficiary

An Optionee may file with the Committee a written designation
of a beneficiary on such form as may be prescribed by the Committee and may,
from time to time, amend or revoke such designation. If no designated
beneficiary survives the Optionee, the executor or administrator of the
Optionee's estate shall be deemed to be the Optionee's beneficiary.

13. Agreement by Optionee Regarding Withholding Taxes

If the Committee shall so require, as a condition of exercise
of an Option granted hereunder, each Optionee shall agree that no later than the
date of exercise, the Optionee will pay to the Company or make arrangements
satisfactory to the Committee regarding payment of any federal, state or local
taxes of any kind required by law to be withheld upon the exercise of an Option.
To the extent provided in the applicable Option Agreement, such payment may be
made by the Optionee with shares of Common Stock (whether previously owned by,
or issuable upon the exercise of an Option awarded to, such Optionee) having a
Fair Market Value equal to the amount of such taxes. Alternatively, the
Committee may provide that an Optionee may elect, to the extent permitted or
required by law, to have the Company deduct federal, state and local taxes of
any kind required by law to be withheld upon the exercise of an Option from any
payment of any kind due to the Optionee.

14. Rights as a Stockholder

An Optionee or a transferee of an award shall have no rights
as a stockholder with respect to any shares of Common Stock covered by the
Option until the date of the issuance of a stock certificate to him for such
shares. No adjustment shall be made for dividends (ordinary or extraordinary,
whether in cash, securities or other property) or distributions of other rights
for which the record date is prior to the date such stock certificate is issued,
except as provided in Section 9 hereof.

15. No Rights to Employment

Nothing contained in the Plan or in any option granted under
the Plan shall confer upon any option holder any right with respect to the
continuation of his employment by the Company (or any subsidiary) or interfere
in any way with the right of the Company (or any subsidiary), subject to the
terms of any separate employment agreement to the contrary, at any time to
terminate such employment or to increase or decrease the compensation of the
option holder from the rate in existence at the time of the grant of an option.
Whether an authorized leave of absence, or absence in military or government
service, shall constitute termination of employment shall be determined by the
Committee at the time.


B-6


16. Approval of Stockholders

The Plan, and any grants of Options thereunder, shall be
subject to approval by the holder(s) of a majority of the issued and outstanding
shares of the Company's capital stock which are entitled to vote on the subject
matter thereof and are present in person or represented by proxy at a
duly-called meeting of the stockholders of the Company which approval must occur
within one year after the date that the Plan is adopted by the Board. In the
event that the stockholders of the Company do not approve the Plan at a meeting
of the stockholders at which such issue is considered and voted upon, then, upon
such event, this Plan and all rights hereunder or under any Option Agreement
entered into in connection herewith shall immediately terminate and no Optionee
(or any permitted transferee thereof) shall have any remaining rights under the
Plan.

17. Amendment and Termination of the Plan

The Board at any time and from time to time may suspend,
terminate, modify or amend the Plan; provided, however, that any amendment that
would materially increase the aggregate number of shares of Common Stock as to
which awards may be granted under the Plan or materially increase the benefits
accruing to Optionees under the Plan or materially modify the requirements as to
eligibility for participation in the Plan shall be subject to the approval of
the holders of a majority of the Common Stock issued and outstanding, except
that any such increase or modification that may result from adjustments
authorized by Section 9 hereof shall not require such approval. Except as
provided in Section 9 hereof, no suspension, termination, modification or
amendment of the Plan may adversely affect any award previously granted, without
the express written consent of the Optionee.

18. Compliance with Section 16(b)

In the case of Optionees who are or may be subject to Section
16 of the 1934 Act, it is the intent of the Company that the Plan and any award
granted hereunder satisfy and be interpreted in a manner that satisfies the
applicable requirements of Rule 16b-3 so that such persons will be entitled to
the benefits of Rule 16b-3 or other exemptive rules under Section 16 of the 1934
Act and will not be subjected to liability thereunder. If any provision of the
Plan or any award would otherwise conflict with the intent expressed herein,
that provision, to the extent possible, shall be interpreted and deemed amended
so as to avoid such conflict. To the extent of any remaining irreconcilable
conflict with such intent, such provision shall be deemed void as applicable to
Optionees who are or may be subject to Section 16 of the 1934

19. Restrictions on Issue of Shares.

(a) Notwithstanding the provisions of Section 8, the Company may delay
the issuance of shares of Common Stock covered by the exercise of an option and
the delivery of a certificate for such shares of Common Stock until the delivery
or distribution of any shares of Common Stock issued under this Plan complies
with all applicable laws (including without limitation, the Securities Act of
1933, as amended), and with the applicable rules of any stock exchange upon
which the shares of Common Stock of the Company are listed or traded.

(b) It is intended that all exercises of options shall be effective,
and the Company shall use its best efforts to bring about compliance with all
applicable legal and regulatory requirements within a reasonable time, except
that the Company shall be under no obligation to qualify shares of Common Stock
or to cause a registration statement or a post-effective amendment to any
registration statement to be prepared for the purpose of covering the issue of
shares of Common Stock in respect of which any option may be exercised, except
as otherwise agreed to by the Company in writing.



B-7


20. Loans.

The Company may make loans to Optionees to permit them to exercise
options. If loans are made, the requirements of all applicable Federal and state
laws and regulations regarding such loans must be met.

21. Modification of Outstanding Options.

The Committee may authorize the amendment of any outstanding option
with the consent of the Optionee when and subject to such conditions as are
deemed to be in the best interests of the Company and in accordance with the
purposes of this Plan.

22. Reservation of Stock.

The Company shall at all times during the term of the Plan reserve and
keep available such number of shares of Common Stock as will be sufficient to
satisfy the requirements of the Plan and shall pay all fees and expenses
necessarily incurred by the Company in connection therewith.

23. Limitation of Rights in the Option Shares.

Any communication or notice required or permitted to be given under the
Plan shall be in writing, and mailed by registered or certified mail or
delivered by hand, if to the Company, to its principal place of business,
attention: President, and, if to an Optionee, to the address as appearing on the
records of the Company.

24. Governing Law

The Plan and all determinations made and actions taken
pursuant hereto shall be governed by the laws of the State of Delaware without
giving effect to the conflict of laws principles thereof.

25. Effective Date and Duration of the Plan.

(a) This Plan shall, subject to Section 16 hereof, be
effective as of June 30, 2000, the date of its adoption by the Board of
Directors, and shall terminate on the later of (a) the tenth anniversary of the
date so determined or (b) the last expiration of awards granted hereunder.







B-8


PROXY
CYTOCLONAL PHARMACEUTICS INC.

2110 RESEARCH ROW, SUITE 621, DALLAS, TEXAS 75235

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned hereby appoints Ronald L. Goode, Ph.D. and Daniel
Shusterman, J.D. as proxies ("Proxies"), each with the power to appoint his
substitute, and hereby authorizes them to represent and to vote, as designated
below, all the entitled voting stock of Cytoclonal Pharmaceutics Inc., a
Delaware Company (the "Company"), held of record by the undersigned on April 16,
2001, at the Annual Meeting of Stockholders to be held at 2110 Research Row,
Suite 601, Dallas, Texas 75235, on June 4, 2001, 9:00 a.m., local time or any
adjournment thereof.

PROPOSAL 1. ELECTION OF DIRECTORS.

Nominees: Arthur P. Bollon, Ph.D., Robert J. Easton, Gary E.
Frashier, Ira J. Gelb, M.D., Ronald Lane Goode, Ph.D., Irwin C.
Gerson and Walter M. Lovenberg, Ph.D.

[ ] FOR all nominees [ ] WITHHOLDING AUTHORITY
(except as marked to the contrary below) as to all nominees

(INSTRUCTION: To withhold authority to vote for any individual nominee, print
that nominee's name on the line provided below.)

Withheld for:
-------------------------------------------

PROPOSAL 2. RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

To ratify selection of Ernst & Young LLP as independent auditors of
the Company for its fiscal year ending December 31, 2001.

[ ] FOR [ ] AGAINST [ ] ABSTAIN

PROPOSAL 3. APPROVAL OF AMENDMENT TO THE COMPANY'S 2000 STOCK OPTION PLAN TO (I)
INCREASE THE NUMBER OF SHARES OF COMMON STOCK AVAILABLE FOR GRANT
THEREUNDER FROM 1,500,000 TO 2,750,000, (II) CHANGE THE VESTING
PERIOD FOR OPTIONS AND (III) PERMIT NEW OPTION HOLDERS AND EXISTING
OPTION HOLDERS TO EXERCISE THEIR OPTIONS BY CASHLESS EXERCISE OF
THEIR OPTIONS OR OTHER MEANS.

[ ] FOR [ ] AGAINST [ ] ABSTAIN

IN THEIR DISCRETION, THE PROXIES ARE AUTHORIZED TO VOTE UPON SUCH OTHER
BUSINESS AS MAY PROPERLY COME BEFORE THE ANNUAL MEETING. THIS PROXY WHEN
PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED HEREIN BY THE UNDERSIGNED
STOCKHOLDER. IF NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR PROPOSALS 1
THROUGH 3.


PLEASE SIGN EXACTLY AS NAME APPEARS BELOW.
WHEN SHARES ARE HELD BY JOINT TENANTS, BOTH
SHOULD SIGN.

Dated:___________, 2001


Signature:
--------------------------------------------

Print Name:
-------------------------------------------




Signature if held jointly:
----------------------------

(When signing as attorney, executor, administrator, trustee or
guardian, please give full title as such. If a Company, please sign in full
corporate name by President or other authorized officer. If a partnership,
please sign in partnership name by authorized person.)