ÄÐÈ˹¬µî

Form: 4

Statement of changes in beneficial ownership of securities

May 17, 2024

JOINT FILER INFORMATION

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Name: Frost Gamma Investments Trust

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Address:

4400 Biscayne Blvd.

Miami, FL 33137

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Designated Filer: Phillip Frost, M.D.

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Issuer Name and Ticker Symbol: ÄÐÈ˹¬µî. (OPK)

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Date of Earliest Transaction: May 17, 2024

Relationship to Issuer: 10% Owner

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FROST GAMMA INVESTMENTS TRUST

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By: /s/ Phillip Frost, M.D., as Trustee

Phillip Frost, M.D., Trustee

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